Cell-Cell Communication in Bacteria Bonnie Bassler, June 2008 Howard Hughes Medical Institute and Princeton University

Lecture Overview Bacteria, primitive single-celled organisms, communicate with chemical languages that allow them to synchronize their behavior and thereby act as enormous multi-cellular organisms. This process is called quorum sensing and it enables bacteria to successfully infect and cause disease in plants, animals, and humans. Investigations of the molecular mechanisms underlying quorum sensing are leading to the development of novel strategies to interfere with quorum sensing. These strategies form the basis of new therapies to be used as antibiotics.

Part 1: Bacterial Quorum Sensing: Intra- and Inter-Species Communication (53:48) Click image above to start seminar in 320x240 format Click here to view in larger 640x480 format* test movie   QuickTime 7 Required    *640x480 System Requirements (there may be a few seconds delay before seminars start) Downloads in alternative formats: (To Save, Right Click a link below and select "Save Target/Link As") QuickTime (101mb)     MP4 (623mb)     iPod/iPhone Video (623mb) PowerPoint Slides 3/page (240kb) Format Descriptions Download Accelerator/Resume Broken Downloads Software

Part 2: Vibrio Cholerae Quorum Sensing and Developing Novel Antibiotics (19:49) Speaker Bio    Related Articles