Control of Embryonic Axis Formation in Drosophila
Trudi Schupbach, Febuaryl 2009
Princeton University and a Howard Hughes Investigator.
Part 1 How do complex multicellular organisms develop from single celled eggs with a single nucleus? We study this question in the fruitfly, Drosophila. In these insects, as in many other organisms, the major body plan is predetermined during oogenesis, or egg development. In the first part of the lecture, I will give an introduction to oogenesis in Drosophila, and the techniques we use to find genes that are responsible for determining the major axes of the egg and embryo. Interestingly, our analysis revealed that this process requires cell to cell communication between the oocyte and the surrounding follicle cells. It involves a signaling molecule, Gurken, which provides a localized signal from the oocyte to the follicle cells and ultimately sets up both the anterior-posterior as well as the dorso-ventral axis of the egg.
Part 1: Establishing the Axes of the Egg in Drosophila
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2: grk RNA localization
Part 3: Gurken Gradient and Follicle Cell Response